In 1921, following the accession of Transylvania to Romania in accordance with the provisions of the Accession Treaty of Romania during World War I in 1872 founded University of Cluj Napoca (Cluj-Napoca later) in Transylvania with instruction in the Hungarian language was transferred to Szeged. Until 1940, the university training was conducted in four faculties: medicine, mathematics and science, law, and the faculty of arts, languages ​​and history. At this time, one of the university professors was Albert Szent-Györgyi - Nobel Laureate in Physiology or Medicine in 1937.

  In 1940, according to the decision of the Vienna Award, Romania owed to cede part of Transylvania, Hungary, and the university was transferred back to Cluj, which was done, but at the same time in Szeged has opened a new Royal University of Miklos Horthy, which After the war, he was named the University of Szeged. In 1951, the Medical Faculty was abolished - at its base was established Medical Institute. In 1962, the University was named the Hungarian revolutionary poet Attila Jozsef, who in 1924 entered the University of Szeged, but was expelled for his political poems.

  In 2000, the University of Szeged was waiting for a new reorganization, which took place as a result of the union of the University, the Medical University and several other institutions in a single University of Szeged.

One of the attractions of the Cathedral Square - a musical clock, located on the wall of a university building in front of the Cathedral. These unique clock - work watchmaker Franz Tsuri and woodcarver Jozef Culae.