Cathedral of St. Mark is located on the square named after the poet Kacic. It was built in the Baroque style. Construction of the cathedral began in 1700 on the initiative of Bishop Nicholas Bizhankovicha, but was completed only in 1756. That's when it was consecrated Bishop Stephen Blaskovich.

The facade of the church is looking to the southwest, so the towers of the cathedral can be seen from almost anywhere in the city. On the right side from the entrance of the relics of St. Clement, the patron saint of the city of Makarska and its diocese. The relics of the saint were brought from the Roman catacombs in 1725, and since then, are the Cathedral, attracting pilgrims.

On the left side is the altar of Our Lady of the Rosary. The wooden altar of the Virgin and Child in her arms made by masters of the Byzantine school. This altar according to local residents has been made during the plague in 1815. The second altar - in honor of the Holy Cross.

Cathedral was badly damaged during a strong earthquake in 1962 and reconstructed in the decoration of the church were made some changes. After the earthquake were also damaged choirs, and in 1970 was installed in the cathedral of the new body of work of the Slovenian company "Genco".