The museum is located in the old cartoons Baroque building in the center of Mexico City. In 1612 this place was a royal college, but it was built in the 70s of the 18th century. Some of the buildings were rebuilt during the restorations and repairs. Baroque facade and a patio - a vivid example of 18th-century homes. Opposite the main entrance is a long corridor leading to the courtyard. Windows and doors of the facade framed by gray-white stone, and the top is full of floral ornaments.

The museum opened its doors in 1987. Main Collection occupies one of the halls of the first floor, most of them exhibited paintings there are political in nature. They criticize the ousted in 1910 President Porfirio Diaz. Most of the pictures painted by Jose Guadalupe Posada. In nearby "Hall Mexican expressive art", as a rule, temporary exhibitions.

The museum exhibited the works of famous artists of the Mexican José Clemente Orozco and Frida Kahlo. On the upper floor of the museum has a hall Mexican Cartoonists Society. It houses temporary exhibitions, hosts art seminars, conferences and book presentations.

It is worth noting that not all of the museum devoted to the cartoon. Within its walls is carried out and thematic exhibitions, for example, "Cartoon of the 20th century" or "modern pirates". It often hosts seminars on the history and methods of cartoons, history of painting and drawing.