Mexico City Museum is located in a historic 18th-century Baroque palace that once belonged to the Counts of Santiago de Kalimayya, descendants of the famous conquistador Joaquin Cortes. The museum building was built in 1781 by architect Francisco Guerrero Torres. Its facade is covered with volcanic stone tezontlem characteristic baroque buildings. The wall on the southwest side of built stone head of a winged serpent. At the beginning of the 20th century there lived an artist Joaquin Klausell. His studio was located on the third floor and now it is a separate exhibition hall, whose walls are covered with unusual frescos, impressionistic collage.

The museum in this building there since 1964. In 26 halls of the palace displayed the history of Mexico since the time of the Aztecs to the present day. The permanent exhibition is divided into periods: pre-Hispanic, colonial period (16-18 century), 19th century and 20th century. Among the exhibits halls you can see the pre-Hispanic bowls, vessels, urns, archaic Aztec manuscripts, maps and objects of everyday life of the ancient peoples of Mexico. Collection of the colonial period, and 19, of the 20th centuries and includes furniture, ancient vases, pitchers, and art objects, paintings and sculptures. Among other things, the museum has a library, a Mexican poet, writer and politician Khaimah Torres Beaudet. It collected about 10 thousand volumes of articles related to the history of Mexico. The collection is a collection of papers of the 19th century, copies or originals of laws and a huge collection of books about the history of the city.

In the Museum of Mexico City, and are often temporary exhibitions, workshops for children and adults, concerts.