Four-storey building La Salle Hall in neoclassical style was built in 1920-1924 years in the Malate district of Manila. Then it placed the main building of the De La Salle College (now the University of the same name), as in the old building did not have enough space for students. Initially, La Salle Hall had only three floors, the fourth has been overbuilt in the 1990s to accommodate the Christian community of De La Salle Brothers. Today, on the first floor is the College of Business, the second - the Chapel of the Holy Sacrament and the office of the Alumni Association of the University of De La Salle. In 2007, La Salle Hall became the only Filipino building, included in the book "1001 building that you should see before you die: the masterpieces of world architecture."

During the Second World War at the Battle of Manila building was virtually destroyed, it refuge civilians in the city. During the week the building was under artillery fire. Japanese troops occupied the building, turning it into its headquarters. 16 members of the Order of Christian Brothers of De La Salle and 25 civilians were killed by invaders at the Chapel in February 1945. Restoration of the building after the war, took two years and cost about 5000 dollars. In December 1947, the chapel was consecrated by Archbishop O'Doherty in honor of the Blessed Sacrament.